产品货号：
Z35280
中文名称：
P53/TP53抗体
英文名称：
Anti-P53/TP53 Antibody (Clone#1711CT184.18.1)
产品规格：
50μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-P53/TP53 Antibody (Clone#1711CT184.18.1) |
| 指标别名 | Antigen NY CO 13;Cellular tumor antigen p53;LFS1;P53;Phosphoprotein p53;TP53;TRP53;tumor protein p53;Tumor suppressor p53 |
| 克隆性 | Monoclonal |
| 检验物种 | human,African green monkey |
| 应用范围 | WB,IHC |
| 基因名称 | TP53 |
| 克隆号 | 1711CT184.18.1 |
| 抗体来源 | Mouse |
| 免疫原 | This P53 antibody is generated from a mouse immunized with a recombinant protein conjugated synthetic peptide between 1-393 amino acids from human P53. |
| 计算分子量 | 44kDa |
| 成分 | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein G column,followed by dialysis against PBS |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | Acts as a tumor suppressor in many tumor types;induces growth arrest or apoptosis depending on the physiological circumstances and cell type.Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process.One of the activated genes is an inhibitor of cyclin-dependent kinases.Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression,or by repression of Bcl-2 expression.In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis;the function is largely independent of transcription.Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA- Mkln1.LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation.Implicated in Notch signaling cross-over.Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage,thus stopping cell cycle progression.Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters.Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1.Isoform 7 inhibits isoform 1-mediated apoptosis. |
| Uniprot ID | P04637 |
相关搜索：P53/TP53抗体，P53抗体，TP53单抗，Anti-P53/TP53 Antibody (Clone#1711CT184.18.1)